The duo were one of the show's most iconic couples before their recent split.
Nancy then moved on with Kyle Kelly though he tragically took his own life in an emotional suicide storyline.
Meanwhile, Darren appeared settled after moving in with Mandy Richardson.
However, their relationship came crashing down on their wedding day after Darren discovered Mandy was complicit in framing Nancy's son Charlie with the murder of Jordan, when in fact it was her own daughter Ella.
In the trailer Darren and Mandy can be seen having a heated discussion.
The next second The Loft's giant sign comes crashing down as Mandy jumps out the way.
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As the clip ended, This Morning host Philip Schofield chuckled: "Death by sign."
Giving more detail, the show's soap expert exclaimed: "So that was Darren.
"He goes to meet Mandy but is he meeting his maker as well?
"Will he be killed before he can rekindle things with Nancy?"
Elsewhere, Cher is set to terrorise Mercedes McQueen even further.
Over the past few months the gobby newbie has been secretly trying to ruin her life by playing on her longing to become a mum once more.
Mercedes tragically suffered a miscarriage last year after seeing her former captor and serial killer Silas Blissett in the village.
In a dark escalation, Cher looks set to steal Diane O'Connor's newborn baby and framing Mercedes.
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Somehow, Mercedes and the rest of the village end up falling for the trick.
The incident is set to send Diane's OCD into overdrive, with This Morning teasing the storyline will "go nuclear.
Meanwhile, enemies Sienna and Summer are set to explore their love/hate relationship further after last month's kiss.