Multiple people had been found trapped as a result of the collision.
One person was airlifted to hospital, Hucks said.
The Williamsburg County Government confirmed on Facebook that one of its transit buses was involved.
It said: "A Williamsburg County Transit bus was involved in an automobile accident near the Brown’s Ferry community this morning.
"Details to follow."
People posted their prayers and best wishes to those who have tragically died or been injured.
Jackie Bradley Hailes commented: "Praying everyone is OK."
The South Carolina Department of Public Safety confirmed to the Daily Mail that the collision had resulted in multiple injuries.
Roads closed in South Carolina to allow for an investigation include Browns Ferry Road, with motorists advised to find alternative routes.
More to follow…
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